EC 5.3.1.21 - Corticosteroid side-chain-isomerase

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IntEnz Enzyme Nomenclature
EC 5.3.1.21

Names

Accepted name:
corticosteroid side-chain-isomerase
Other name:
11-deoxycorticosterone ketol-isomerase
Systematic name:
11-deoxycorticosterone aldose-ketose-isomerase

Reaction

Comments:

An epimerization at C-20 and C-21 is probably catalysed by the same enzyme.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004110

References

  1. Martin, K.O., Oh, S.-W., Lee, H.J. and Monder, C.
    Studies on 21-3H-labeled corticosteroids: evidence for isomerization of the ketol side chain of 11-deoxycorticosterone by a hamster liver enzyme.
    Biochemistry 16: 3803-3809 (1977). [PMID: 901753]
  2. Monder, C., Martin, K.O. and Bogumil, J.
    Presence of epimerase activity in hamster liver corticosteroid side chain isomerase.
    J. Biol. Chem. 255: 7192-7198 (1980). [PMID: 7391077]

[EC 5.3.1.21 created 1983]