EC - Maleylacetoacetate isomerase

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IntEnz Enzyme Nomenclature


Accepted name:
maleylacetoacetate isomerase
Other names:
maleylacetoacetic isomerase
maleylacetone cis-trans-isomerase
maleylacetone isomerase
Systematic name:
4-maleylacetoacetate cis-trans-isomerase



Also acts on maleylpyruvate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016034
CAS Registry Number: 9023-75-0
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Edwards, S.W. and Knox, W.E.
    Homogentisate metabolism: the isomerization of methylacetoacetate by an enzyme which requires glutathione.
    J. Biol. Chem. 220: 79-91 (1956).
  2. Lack, L.
    Enzymic cis-trans isomerization of maleylpyruvic acid.
    J. Biol. Chem. 236: 2835-2840 (1961).
  3. Seltzer, S.
    Purification and properties of maleylacetone cis-trans isomerase from Vibrio 01.
    J. Biol. Chem. 248: 215-222 (1973). [PMID: 4692831]

[EC created 1961]