EC 5.1.1.20 - L-Ala-D/L-Glu epimerase

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IntEnz Enzyme Nomenclature
EC 5.1.1.20

Names

Accepted name:
L-Ala-D/L-Glu epimerase
Other names:
YkfB
YcjG
AEE
AE epimerase
Systematic name:
L-alanyl-D-glutamate epimerase

Reaction

Comments:

The enzyme, characterized from the bacteria Escherichia coli and Bacillus subtilis, is involved in the recycling of the murein peptide, of which L-Ala-D-Glu is a component. In vitro the enzyme from E.coli epimerizes several L-Ala-L-X dipeptides with broader specificity than the enzyme from B.subtilis. Formerly EC 5.1.1.n1.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Schmidt, D. M., Hubbard, B. K., Gerlt, J. A.
    Evolution of enzymatic activities in the enolase superfamily: functional assignment of unknown proteins in Bacillus subtilis and Escherichia coli as L-Ala-D/L-Glu epimerases.
    Biochemistry 40: 15707-15715 (2001). [PMID: 11747447]
  2. Gulick, A. M., Schmidt, D. M., Gerlt, J. A., Rayment, I.
    Evolution of enzymatic activities in the enolase superfamily: crystal structures of the L-Ala-D/L-Glu epimerases from Escherichia coli and Bacillus subtilis.
    Biochemistry 40: 15716-15724 (2001). [PMID: 11747448]

[EC 5.5.1.20 created 2015]