EC 4.4.1.6 - S-alkylcysteine lyase

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IntEnz Enzyme Nomenclature
EC 4.4.1.6

Names

Accepted name:
S-alkylcysteine lyase
Other names:
S-alkyl-L-cysteinase
S-alkyl-L-cysteine lyase
S-alkyl-L-cysteine sulfoxide lyase
S-alkylcysteinase
alkyl cysteine lyase
alkylcysteine lyase
S-alkyl-L-cysteine alkylthiol-lyase (deaminating)
Systematic name:
S-alkyl-L-cysteine alkylthiol-lyase (deaminating; pyruvate-forming)

Reactions

Cofactor

Comments:

A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing an alkyl thiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Possibly identical, in yeast, with EC 4.4.1.8 cystathionine β-lyase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050271
CAS Registry Number: 62213-27-8

References

  1. Nomura, J., Nishizuka, Y. and Hayaishi, O.
    S-Alkylcysteinase: enzymatic cleavage of S-methyl-L-cysteine and its sulfoxide.
    J. Biol. Chem. 238: 1441-1446 (1963).

[EC 4.4.1.6 created 1965, deleted 1972, reinstated 1976]