EC 4.4.1.5 - Lactoylglutathione lyase

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IntEnz Enzyme Nomenclature
EC 4.4.1.5

Names

Accepted name:
lactoylglutathione lyase
Other names:
aldoketomutase
glyoxylase I
ketone-aldehyde mutase
methylglyoxalase
glyoxalase I
(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing)
Systematic name:
(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)

Reaction

Comments:

Also acts on 3-phosphoglycerol-glutathione.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00720
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004462
CAS Registry Number: 9033-12-9
UniProtKB/Swiss-Prot: (30) [show] [UniProt]

References

  1. Ekwall, K. and Mannervik, B.
    The stereochemical configuration of the lactoyl group of S-lactoylglutathionine formed by the action of glyoxalase I from porcine erythrocytes and yeast.
    Biochim. Biophys. Acta 297: 297-299 (1973). [PMID: 4574550]
  2. Racker, E.
    The mechanism of action of glyoxalase.
    J. Biol. Chem. 190: 685-696 (1951). [PMID: 14841219]

[EC 4.4.1.5 created 1961]