EC 4.4.1.21 - S-ribosylhomocysteine lyase

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IntEnz Enzyme Nomenclature
EC 4.4.1.21

Names

Accepted name:
S-ribosylhomocysteine lyase
Other names:
S-ribosylhomocysteinase
LuxS
Systematic name:
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine L-homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]

Reaction

Cofactor

Comments:

Contains Fe2+. The 4,5-dihydroxypentan-2,3-dione formed spontaneously cyclizes and combines with borate to form an autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which is used by many bacteria to control gene expression in response to cell density [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043768
CAS Registry Number: 37288-63-4
UniProtKB/Swiss-Prot: (288) [show] [UniProt]

References

  1. Zhu, J., Dizin, E., Hu, X., Wavreille, A.S., Park, J. and Pei, D.
    S-Ribosylhomocysteinase (LuxS) is a mononuclear iron protein.
    Biochemistry 42: 4717-4726 (2003). [PMID: 12705835]
  2. Miller, M.B. and Bassler, B.L.
    Quorum sensing in bacteria.
    Annu. Rev. Microbiol. 55: 165-199 (2001). [PMID: 11544353]

[EC 4.4.1.21 created 2004]