EC - Leukotriene-C4 synthase

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IntEnz Enzyme Nomenclature


Accepted name:
leukotriene-C4 synthase
Other names:
(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)
LTC4 synthase
LTC4 synthetase
leukotriene A4:glutathione S-leukotrienyltransferase
leukotriene C4 synthetase
(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)
Systematic name:
leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)



The reaction proceeds in the direction of addition. Not identical with EC, glutathione transferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00999
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004464
CAS Registry Number: 90698-32-1


  1. Bach, M.K., Brashler, J.R. and Morton, D.R., Jr.
    Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase.
    Arch. Biochem. Biophys. 230: 455-465 (1984). [PMID: 6324687]
  2. Shimizu, T.
    Enzymes functional in the syntheses of leukotrienes and related compounds.
    Int. J. Biochem. 20: 661-666 (1988). [PMID: 2846379]
  3. Lam, B.K. and Austen, K.F.
    Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes.
    Prostaglandins Other Lipid Mediat. 68-69: 511-520 (2002). [PMID: 12432940]
  4. Christmas, P., Weber, B.M., McKee, M., Brown, D. and Soberman, R.J.
    Membrane localization and topology of leukotriene C4 synthase.
    J. Biol. Chem. 277: 28902-28908 (2002). [PMID: 12023288]

[EC created 1989 as EC, transferred 2004 to EC]