EC 4.4.1.11 - Methionine γ-lyase

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IntEnz Enzyme Nomenclature
EC 4.4.1.11

Names

Accepted name:
methionine γ-lyase
Other names:
L-methioninase
L-methionine γ-lyase
methioninase
methionine dethiomethylase
methionine lyase
L-methionine methanethiol-lyase (deaminating)
Systematic name:
L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)

Reactions

Cofactor

Comments:

A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing methanethiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme is involved in L-methionine catabolism.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00677
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018826
CAS Registry Number: 42616-25-1
UniProtKB/Swiss-Prot:

References

  1. Kreis, W. and Hession, C.
    Isolation and purification of L-methionine-α-deamino-γ-mercaptomethane-lyase (L-methioninase) from Clostridium sporogenes.
    Cancer Res. 33: 1862-1865 (1973). [PMID: 4720797]

[EC 4.4.1.11 created 1976]