EC - Scytalone dehydratase

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IntEnz Enzyme Nomenclature


Accepted name:
scytalone dehydratase
Other name:
scytalone 7,8-hydro-lyase
Systematic name:
scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)



Involved, with EC tetrahydroxynaphthalene reductase, in the biosynthesis of melanin in pathogenic fungi.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030411


  1. Butler, M.J., Lazarovits, G., Higgins, V.J. and Lachance, M.-A.
    Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp. and other fungi.
    Exp. Mycol. 12: 367-376 (1988).
  2. Tajima, S., Kubo, Y., Furusawa, I. and Shishiyama, J.
    Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus.
    Exp. Mycol. 13: 69 (1989).
  3. Wheeler, M.H. and Greenblatt, G.A.
    The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease.
    Exp. Mycol. 12: 151-160 (1988).

[EC created 1992]