EC - 2-oxopent-4-enoate hydratase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
2-oxopent-4-enoate hydratase
Other names:
2-keto-4-pentenoate hydratase
2-keto-4-pentenoate (vinylpyruvate)hydratase
4-hydroxy-2-oxopentanoate hydro-lyase
mhpD (gene name)
4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)
Systematic name:
(S)-4-hydroxy-2-oxopentanoate hydro-lyase ((2Z)-2-hydroxypenta-2,4-dienoate-forming)



Also acts, more slowly, on cis-2-oxohex-4-enoate, but not on the trans-isomer.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008684
CAS Registry Numbers: 227181-25-1 229017-66-7 64427-80-1
UniProtKB/Swiss-Prot: (24) [show] [UniProt]


  1. Kunz, D.A., Ribbons, D.W. and Chapman, P.J.
    Metabolism of allylglycine and cis-crotylglycine by Pseudomonas putida (arvilla) mt-2 harboring a TOL plasmid.
    J. Bacteriol. 148: 72-82 (1981). [PMID: 7287632]
  2. Pollard, J. R., Bugg, T. D.
    Purification, characterisation and reaction mechanism of monofunctional 2-hydroxypentadienoic acid hydratase from Escherichia coli.
    Eur. J. Biochem. 251: 98-106 (1998). [PMID: 9492273]

[EC created 1984]