EC 4.2.1.75 - Uroporphyrinogen-III synthase

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IntEnz Enzyme Nomenclature
EC 4.2.1.75

Names

Accepted name:
uroporphyrinogen-III synthase
Other names:
URO-synthase
porphobilinogenase
uroporphyrinogen III cosynthase
uroporphyrinogen isomerase
uroporphyrinogen-III cosynthetase
uroporphyrinogen-III cosynthase
hydroxymethylbilane hydro-lyase (cyclizing)
Systematic name:
hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)

Reaction

Comments:

In the presence of EC 2.5.1.61 hydroxymethylbilane synthase, enzyme forms uroporphyrinogen III from porphobilinogen.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004852
CAS Registry Number: 37340-55-9
UniProtKB/Swiss-Prot: (18) [show] [UniProt]

References

  1. Battersby, A.R., Fookes, C.J.R., Matcham, G.W.J. and McDonald, E.
    Biosynthesis of the pigments of life: formation of the macrocycle.
    Nature 285: 17-21 (1980). [PMID: 6769048]
  2. Tsai, S.-F., Bishop, D.F. and Desnick, R.J.
    Purification and properties of uroporphyrinogen III synthase from human erythrocytes.
    J. Biol. Chem. 262: 1268-1273 (1987). [PMID: 3805019]

[EC 4.2.1.75 created 1982]