EC - Urocanate hydratase

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IntEnz Enzyme Nomenclature


Accepted name:
urocanate hydratase
Other names:
imidazolonepropionate hydrolase
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase
Systematic name:
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)




Contains tightly bound NAD+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00947
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016153
CAS Registry Number: 9014-58-8
UniProtKB/Swiss-Prot: (170) [show] [UniProt]


  1. Rétey, J.
    The urocanase story: a novel role of NAD+ as electrophile.
    Arch. Biochem. Biophys. 314: 1-16 (1994). [PMID: 7944380]
  2. Hassall, H. and Greenberg, D.M.
    Urocanase (beef liver).
    Methods Enzymol. 17B: 365-380 (1970).
  3. Kaminskas, E., Kimhi, Y. and Magasanik, B.
    Urocanase and N-formimino-L-glutamate formiminohydrolase of Bacillus subtilis, two enzymes of the histidine degradation pathway.
    J. Biol. Chem. 245: 3536-3544 (1970). [PMID: 4990470]
  4. Swaine, D.
    The effect of substrate analogues on the activity of cat liver urocanase.
    Biochim. Biophys. Acta 178: 609-618 (1969). [PMID: 5784906]

[EC created 1972, modified 2001]