EC 4.2.1.46 - DTDP-glucose 4,6-dehydratase

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IntEnz Enzyme Nomenclature
EC 4.2.1.46

Names

Accepted name:
dTDP-glucose 4,6-dehydratase
Other names:
TDP-glucose oxidoreductase
dTDPglucose 4,6-dehydratase
dTDPglucose 4,6-hydro-lyase
thymidine diphosphoglucose oxidoreductase
dTDP-glucose 4,6-hydro-lyase
dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)
Systematic name:
dTDP-α-D-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)

Reaction

Cofactor

Comments:

Requires bound NAD+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008460
CAS Registry Number: 37259-54-4
UniProtKB/Swiss-Prot: (26) [show] [UniProt]

References

  1. Gilbert, J.M., Matsuhashi, M. and Strominger, J.L.
    Thymidine diphosphate 4-acetamido-4,6-dideoxyhexoses. II. Purification and properties of thymidine diphosphate D-glucose oxidoreductase.
    J. Biol. Chem. 240: 1305-1308 (1965). [PMID: 14284740]
  2. Melo, A., Elliott, H. and Glaser, L.
    The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase.
    J. Biol. Chem. 243: 1467-1774 (1968). [PMID: 4869560]
  3. Wang, S.-F. and Gabriel, O.
    Biological mechanisms involved in the formation of deoxy sugars. V. Isolation and crystallization of thymidine diphosphate-D-glucose oxidoreductase from Escherichia coli B.
    J. Biol. Chem. 244: 3430-3437 (1969). [PMID: 4307450]
  4. Hegeman, A. D., Gross, J. W., Frey, P. A.
    Probing catalysis by Escherichia coli dTDP-glucose-4,6-dehydratase: identification and preliminary characterization of functional amino acid residues at the active site.
    Biochemistry 40: 6598-6610 (2001). [PMID: 11380254]
  5. Gross, J. W., Hegeman, A. D., Gerratana, B., Frey, P. A.
    Dehydration is catalyzed by glutamate-136 and aspartic acid-135 active site residues in Escherichia coli dTDP-glucose 4,6-dehydratase.
    Biochemistry 40: 12497-12504 (2001). [PMID: 11601973]

[EC 4.2.1.46 created 1972]