EC - Galactarate dehydratase

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IntEnz Enzyme Nomenclature


Accepted name:
galactarate dehydratase
Other names:
D-galactarate hydro-lyase
D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)
talrD (gene name)/galrD (gene name)
Systematic name:
galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)



The enzyme from the bacterium Escherichia coli is specific for galactarate [2], while the enzyme from Salmonella typhimurium also has activity with L-talarate (cf. EC, L-talarate dehydratase) [3]. cf. EC, galactarate dehydratase (D-threo-forming).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008867
CAS Registry Number: 37290-78-1


  1. Blumenthal, H.J. and Jepson, T.
    Galactarate dehydrase.
    Methods Enzymol. 9: 665-669 (1966).
  2. Hubbard, B. K., Koch, M., Palmer, D. R., Babbitt, P. C., Gerlt, J. A.
    Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli.
    Biochemistry 37: 14369-14375 (1998). [PMID: 9772162]
  3. Yew, W. S., Fedorov, A. A., Fedorov, E. V., Almo, S. C., Gerlt, J. A.
    Evolution of enzymatic activities in the enolase superfamily: L-talarate/galactarate dehydratase from Salmonella typhimurium LT2.
    Biochemistry 46: 9564-9577 (2007). [PMID: 17649980]
  4. Rakus, J. F., Kalyanaraman, C., Fedorov, A. A., Fedorov, E. V., Mills-Groninger, F. P., Toro, R., Bonanno, J., Bain, K., Sauder, J. M., Burley, S. K., Almo, S. C., Jacobson, M. P., Gerlt, J. A.
    Computation-facilitated assignment of the function in the enolase superfamily: a regiochemically distinct galactarate dehydratase from Oceanobacillus iheyensis .
    Biochemistry 48: 11546-11558 (2009). [PMID: 19883118]

[EC created 1972, modified 2015]