EC 22.214.171.124 - Galactarate dehydratase
IntEnz Enzyme Nomenclature
D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)
talrD (gene name)/galrD (gene name)
16005 [IUBMB]galactarategalactarateName origin: UniProt - CHECKED (C)Formula: C6H8O8
Charge: -2ChEBI compound status: CHECKED (C)<?>5-dehydro-4-deoxy-D-glucarate5-dehydro-4-deoxy-D-glucarateName origin: UniProt - CHECKED (C)Formula: C6H6O7
Charge: -2ChEBI compound status: CHECKED (C)
The enzyme from the bacterium Escherichia coli is specific for galactarate , while the enzyme from Salmonella typhimurium also has activity with L-talarate (cf. EC 126.96.36.199, L-talarate dehydratase) . cf. EC 188.8.131.52, galactarate dehydratase (D-threo-forming).
Links to other databases
Galactarate dehydrase.Methods Enzymol. 9: 665-669 (1966).
Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli.Biochemistry 37: 14369-14375 (1998). [PMID: 9772162]
Evolution of enzymatic activities in the enolase superfamily: L-talarate/galactarate dehydratase from Salmonella typhimurium LT2.Biochemistry 46: 9564-9577 (2007). [PMID: 17649980]
Computation-facilitated assignment of the function in the enolase superfamily: a regiochemically distinct galactarate dehydratase from Oceanobacillus iheyensis .Biochemistry 48: 11546-11558 (2009). [PMID: 19883118]
[EC 184.108.40.206 created 1972, modified 2015]