IntEnz - EC 4.2.1.35

EC 4 - Lyases

EC 4.2 - Carbon-oxygen lyases

EC 4.2.1 - Hydro-lyases

EC 4.2.1.35 - (R)-2-methylmalate dehydratase

IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 4.2.1.35

Names

Accepted name:

(R)-2-methylmalate dehydratase

Other names:

(−)-citramalate hydro-lyase
citraconase
citraconate hydratase
citramalate hydro-lyase
(R)-2-methylmalate hydro-lyase

Systematic name:

(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)

Reactions

22332 [IUBMB]

(3R)-citramalate

(3R)-citramalate

Name origin: UniProt - CHECKED (C)

CHEBI:30934

Formula: C5H6O5
Charge: -2

ChEBI compound status: CHECKED (C)

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2-methylmaleate

2-methylmaleate

Name origin: UniProt - CHECKED (C)

CHEBI:30719

Formula: C5H4O4
Charge: -2

ChEBI compound status: CHECKED (C)

+

H₂O

H2O

Name origin: UniProt - CHECKED (C)

CHEBI:15377

Formula: H2O
Charge: 0

ChEBI compound status: CHECKED (C)
42424

2-methylmaleate

2-methylmaleate

Name origin: UniProt - CHECKED (C)

CHEBI:30719

Formula: C5H4O4
Charge: -2

ChEBI compound status: CHECKED (C)

+

H₂O

H2O

Name origin: UniProt - CHECKED (C)

CHEBI:15377

Formula: H2O
Charge: 0

ChEBI compound status: CHECKED (C)

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(2R,3S)-3-methylmalate

(2R,3S)-3-methylmalate

Name origin: UniProt - CHECKED (C)

CHEBI:58511

Formula: C5H6O5
Charge: -2

ChEBI compound status: CHECKED (C)

Cofactor

Fe cation

Comments:

Requires Fe²⁺.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0047508

CAS Registry Number: 9027-92-3

UniProtKB/Swiss-Prot:

LEUC_METJA

LEUD_METJA

References

Subramanian, S.S. and Raghavendra Rao, M.R.

Purification and properties of citraconase.

J. Biol. Chem. 243: 2367-2372 (1968). [PMID: 4296839]

[EC 4.2.1.35 created 1972]