EC - 3-dehydroshikimate dehydratase

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IntEnz Enzyme Nomenclature


Accepted name:
3-dehydroshikimate dehydratase
Systematic name:
3-dehydroshikimate hydro-lyase




Catalyses an early step in the biosynthesis of petrobactin, a siderophore produced by many bacteria, including the human pathogen Bacillus anthracis. Requires divalent ions, with a preference for Mn2+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Fox, D. T., Hotta, K., Kim, C. Y., Koppisch, A. T.
    The missing link in petrobactin biosynthesis: asbF encodes a (−)-3-dehydroshikimate dehydratase.
    Biochemistry 47: 12251-12253 (2008). [PMID: 18975921]
  2. Pfleger, B. F., Kim, Y., Nusca, T. D., Maltseva, N., Lee, J. Y., Rath, C. M., Scaglione, J. B., Janes, B. K., Anderson, E. C., Bergman, N. H., Hanna, P. C., Joachimiak, A., Sherman, D. H.
    Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis.
    Proc. Natl. Acad. Sci. USA 105: 17133-17138 (2008). [PMID: 18955706]

[EC created 2009]