EC 4.1.3.38 - Aminodeoxychorismate lyase

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IntEnz Enzyme Nomenclature
EC 4.1.3.38

Names

Accepted name:
aminodeoxychorismate lyase
Other names:
4-amino-4-deoxychorismate lyase
enzyme X
ADC lyase
4-amino-4-deoxychorismate pyruvate-lyase
Systematic name:
4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)

Reaction

Cofactor

Comments:

A pyridoxal-phosphate protein. Forms part of the folate biosynthesis pathway. Acts on 4-amino-4-deoxychorismate, the product of EC 2.6.1.85, aminodeoxychorismate synthase, to form p-aminobenzoate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008696
UniProtKB/Swiss-Prot:

References

  1. Ye, Q.Z., Liu, J. and Walsh, C.T.
    p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase.
    Proc. Natl. Acad. Sci. USA 87: 9391-9395 (1990). [PMID: 2251281]
  2. Green, J.M., Merkel, W.K. and Nichols, B.P.
    Characterization and sequence of Escherichia coli pabC, the gene encoding aminodeoxychorismate lyase, a pyridoxal phosphate-containing enzyme.
    J. Bacteriol. 174: 5317-5323 (1992). [PMID: 1644759]
  3. Nakai, T., Mizutani, H., Miyahara, I., Hirotsu, K., Takeda, S., Jhee, K.H., Yoshimura, T. and Esaki, N.
    Three-dimensional structure of 4-amino-4-deoxychorismate lyase from Escherichia coli.
    J. Biochem. 128: 29-38 (2000). [PMID: 10876155]

[EC 4.1.3.38 created 2003]