EC - 1,4-dihydroxy-2-naphthoyl-CoA synthase

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IntEnz Enzyme Nomenclature


Accepted name:
1,4-dihydroxy-2-naphthoyl-CoA synthase
Other names:
1,4-dihydroxy-2-naphthoate synthase
dihydroxynaphthoate synthase
dihydroxynaphthoic acid synthetase
DHNA synthetase
o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing)
naphthoate synthase
o-succinylbenzoyl-CoA dihydratase (cyclizing)
Systematic name:
4-(2-carboxyphenyl)-4-oxobutanoyl-CoA dihydratase (cyclizing)



This enzyme is involved in the synthesis of 1,4-dihydroxy-2-naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K2, in bacteria), phylloquinone (vitamin K1 in plants), and many plant pigments. The coenzyme A group is subsequently removed from the product by EC, 1,4-dihydroxy-2-naphthoyl-CoA hydrolase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00150
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008935
CAS Registry Number: 61328-42-5
UniProtKB/Swiss-Prot: (21) [show] [UniProt]


  1. Meganathan, R., Bentley, R.
    Menaquinone (vitamin K2) biosynthesis: conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes.
    J. Bacteriol. 140: 92-98 (1979). [PMID: 500558]
  2. Kolkmann, R., Leistner, E.
    4-(2'-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K2 (menaquinone) biosynthesis.
    Z. Naturforsch. C: Biosci. 42: 1207-1214 (1987). [PMID: 2966501]
  3. Johnson, T. W., Shen, G., Zybailov, B., Kolling, D., Reategui, R., Beauparlant, S., Vassiliev, I. R., Bryant, D. A., Jones, A. D., Golbeck, J. H., Chitnis, P. R.
    Recruitment of a foreign quinone into the A1 site of photosystem I. I. Genetic and physiological characterization of phylloquinone biosynthetic pathway mutants in Synechocystis sp. PCC 6803.
    J. Biol. Chem. 275: 8523-8530 (2000). [PMID: 10722690]
  4. Truglio, J. J., Theis, K., Feng, Y., Gajda, R., Machutta, C., Tonge, P. J., Kisker, C.
    Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis.
    J. Biol. Chem. 278: 42352-42360 (2003). [PMID: 12909628]

[EC created 1992, modified 2010]