EC 4.1.3.30 - Methylisocitrate lyase

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IntEnz Enzyme Nomenclature
EC 4.1.3.30

Names

Accepted name:
methylisocitrate lyase
Other names:
2-methylisocitrate lyase
MICL
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase
Systematic name:
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)

Reaction

Comments:

The enzyme acts on threo-Ds-2-methylisocitrate, but not on threo-Ds-isocitrate, threo-DL-isocitrate or erythro-Ls-isocitrate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0046421
CAS Registry Number: 57827-77-7
UniProtKB/Swiss-Prot: (39) [show] [UniProt]

References

  1. Tabuchi, T. and Satoh, T.
    Distinction between isocitrate lyase and methylisocitrate lyase in Candida lipolytica.
    Agric. Biol. Chem. 40: 1863-1869 (1976).
  2. Tabuchi, T. and Satoh, T.
    Purification and properties of methylisocitrate lyase, a key enzyme in propionate metabolism, from Candida lipolytica.
    Agric. Biol. Chem. 41: 169-174 (1977).

[EC 4.1.3.30 created 1978]