EC - N-acetylneuraminate lyase

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IntEnz Enzyme Nomenclature


Accepted name:
N-acetylneuraminate lyase
Other names:
N-acetylneuraminate aldolase
N-acetylneuraminic acid aldolase
N-acetylneuraminic acid lyase
N-acetylneuraminic aldolase
N-acetylneuraminic lyase
NANA lyase
acetylneuraminate lyase
acetylneuraminate pyruvate-lyase
neuraminate aldolase
neuraminic acid aldolase
neuraminic aldolase
sialate lyase
sialic acid aldolase
sialic aldolase
N-acetylneuraminate pyruvate-lyase
Systematic name:
N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)



Also acts on N-glycoloylneuraminate, and on O-acetylated sialic acids, other than 4-O-acetylated derivatives.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00569
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008747
CAS Registry Number: 9027-60-5
UniProtKB/Swiss-Prot: (84) [show] [UniProt]


  1. Comb, D.G. and Roseman, S.
    The sialic acids. I. The structure and enzymatic synthesis of N-acetylneuraminic acid.
    J. Biol. Chem. 235: 2529-2537 (1960). [PMID: 13811398]
  2. Schauer, R.
    Chemistry, metabolism, and biological functions of sialic acids.
    Adv. Carbohydr. Chem. Biochem. 40: 131-234 (1982). [PMID: 6762816]

[EC created 1961]