EC 22.214.171.124 - Anthranilate synthase
IntEnz Enzyme Nomenclature
chorismate pyruvate-lyase (amino-accepting)
- chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate
In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan [EC 126.96.36.199 (anthranilate phosphoribosyltransferase ), EC 188.8.131.52 (indole-3-glycerol-phosphate synthase), EC 184.108.40.206 (tryptophan synthase) and EC 220.127.116.11 (phosphoribosylanthranilate isomerase)]. The native enzyme in the complex uses either glutamine or, less efficiently, NH3. The enzyme separated from the complex uses NH3 only.
Links to other databases
Anthranilate synthetase. Partial purification and some kinetic studies on the enzyme from Escherichia coli.J. Biol. Chem. 241: 5577-5584 (1966). [PMID: 5333199]
Chorismate to tryptophan (Escherichia coli) - anthranilate synthetase, PR transferase, PRA isomerase, InGP synthetase, tryptophan synthetase.Methods Enzymol. 17A: 365-380 (1970).
Tryptophan biosynthetic genes in eukaryotic microorganisms.Annu. Rev. Microbiol. 40: 55-77 (1986).
Anthranilate synthetase, an enzyme specified by the tryptophan operon of Escherichia coli: Comparative studies on the complex and the subunits.J. Bacteriol. 97: 734-742 (1969). [PMID: 4886290]
Anthranilate synthetase. Purification and properties of component I from Salmonella typhimurium.Biochemistry 7: 3566-3573 (1968). [PMID: 4878701]
[EC 18.104.22.168 created 1972]