EC 4.1.2.14 - 2-dehydro-3-deoxy-phosphogluconate aldolase

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IntEnz Enzyme Nomenclature
EC 4.1.2.14

Names

Accepted name:
2-dehydro-3-deoxy-phosphogluconate aldolase
Other names:
2-keto-3-deoxy-6-phosphogluconate aldolase
2-keto-3-deoxy-6-phosphogluconic aldolase
2-keto-3-deoxygluconate-6-P-aldolase
2-keto-3-deoxygluconate-6-phosphate aldolase
2-oxo-3-deoxy-6-phosphogluconate aldolase
6-phospho-2-keto-3-deoxygluconate aldolase
KDPG aldolase
ODPG aldolase
phospho-2-keto-3-deoxygluconate aldolase
phospho-2-keto-3-deoxygluconic aldolase
phospho-2-dehydro-3-deoxygluconate aldolase
KDPG-aldolase
2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase
2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)
Systematic name:
2-dehydro-3-deoxy-6-phospho-D-gluconate D-glyceraldehyde-3-phospho-lyase (pyruvate-forming)

Reaction

Comments:

The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D-galactonate. cf. EC 4.1.2.55, 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase [2]. Also acts on 2-oxobutanoate [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00144
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008675
CAS Registry Number: 9024-53-7
UniProtKB/Swiss-Prot: (14) [show] [UniProt]

References

  1. Meloche, H.P. and Wood, W.A.
    Crystallization and characteristics of 2-keto-3-deoxy-6-phosphogluconic aldolase.
    J. Biol. Chem. 239: 3515-3518 (1964). [PMID: 14245411]
  2. Barran, L. R., Wood, W. A.
    The mechanism of 2-keto-3-deoxy-6-phosphogluconate aldolase. 3. Nature of the inactivation by fluorodinitrobenzene.
    J. Biol. Chem. 246: 4028-4035 (1971). [PMID: 5561473]

[EC 4.1.2.14 created 1965, modified 1976, modified 2014]