EC 126.96.36.199 - Glutaconyl-CoA decarboxylase
IntEnz Enzyme Nomenclature
- 4-carboxybut-2-enoyl-CoA = but-2-enoyl-CoA + CO2
The enzyme from Acidaminococcus fermentans is a biotinyl-protein, requires Na+, and acts as a sodium pump. Prior to the Na+-dependent decarboxylation, the carboxylate is transferred to biotin in a Na+-independent manner. The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme.
Links to other databases
Purification, characterisation and reconstitution of glutaconyl-CoA decarboxylase, a biotin-dependent sodium pump from anaerobic bacteria.Eur. J. Biochem. 136: 427-434 (1983). [PMID: 6628393]
Sodium ion-translocating decarboxylases.Biochim. Biophys. Acta 1505: 15-27 (2001). [PMID: 11248185]
[EC 188.8.131.52 created 1986, modified 2003]