EC - Glutaconyl-CoA decarboxylase

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IntEnz Enzyme Nomenclature


Accepted name:
glutaconyl-CoA decarboxylase
Other names:
glutaconyl coenzyme A decarboxylase
pent-2-enoyl-CoA carboxy-lyase
4-carboxybut-2-enoyl-CoA carboxy-lyase
Systematic name:
4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)




The enzyme from Acidaminococcus fermentans is a biotinyl-protein, requires Na+, and acts as a sodium pump. Prior to the Na+-dependent decarboxylation, the carboxylate is transferred to biotin in a Na+-independent manner. The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00167 , PROSITE:PDOC50980
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018801


  1. Buckel, W.S. and Semmler, R.
    Purification, characterisation and reconstitution of glutaconyl-CoA decarboxylase, a biotin-dependent sodium pump from anaerobic bacteria.
    Eur. J. Biochem. 136: 427-434 (1983). [PMID: 6628393]
  2. Buckel, W.
    Sodium ion-translocating decarboxylases.
    Biochim. Biophys. Acta 1505: 15-27 (2001). [PMID: 11248185]

[EC created 1986, modified 2003]