EC 4.1.1.41 - Methylmalonyl-CoA decarboxylase

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IntEnz Enzyme Nomenclature
EC 4.1.1.41

Names

Accepted name:
methylmalonyl-CoA decarboxylase
Other names:
(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase [incorrect]
methylmalonyl-coenzyme A decarboxylase
propionyl coenzyme A carboxylase [incorrect]
propionyl-CoA carboxylase [incorrect]
(S)-methylmalonyl-CoA carboxy-lyase
Systematic name:
(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)

Reaction

Cofactor

Comments:

The enzyme from Veillonella alcalescens is a biotinyl-protein, requires Na+ and acts as a sodium pump.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004492
CAS Registry Number: 37289-44-4
UniProtKB/Swiss-Prot: (10) [show] [UniProt]

References

  1. Galivan, J.H. and Allen, S.H.G.
    Methylmalonyl coenzyme A decarboxylase. Its role in succinate decarboxylation by Micrococcus lactilyticus.
    J. Biol. Chem. 243: 1253-1261 (1968). [PMID: 5646172]
  2. Hilpert, W. and Dimroth, P.
    Conversion of the chemical energy of methylmalonyl-CoA decarboxylation into a Na+ gradient.
    Nature 296: 584-585 (1982). [PMID: 7070502]
  3. Hoffmann, A., Hilpert, W. and Dimroth, P.
    The carboxyltransferase activity of the sodium-ion-translocating methylmalonyl-CoA decarboxylase of Veillonella alcalescens.
    Eur. J. Biochem. 179: 645-650 (1989). [PMID: 2920730]

[EC 4.1.1.41 created 1972, modified 1983, modified 1986, modified 2004]