EC - Phosphoenolpyruvate carboxykinase (GTP)

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IntEnz Enzyme Nomenclature


Accepted name:
phosphoenolpyruvate carboxykinase (GTP)
Other names:
PEP carboxylase
phosphoenolpyruvate carboxykinase
phosphoenolpyruvate carboxylase
phosphoenolpyruvic carboxykinase
phosphoenolpyruvic carboxykinase (GTP)
phosphoenolpyruvic carboxylase (GTP)
phosphopyruvate (guanosine triphosphate) carboxykinase
phosphopyruvate carboxylase
phosphopyruvate carboxylase (GTP)
PEP carboxykinase
GTP:oxaloacetate carboxy-lyase (transphosphorylating)
Systematic name:
GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)



ITP can act as phosphate donor.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00421
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004613
CAS Registry Number: 9013-08-5
UniProtKB/Swiss-Prot: (94) [show] [UniProt]


  1. Change, H.-C. and Lane, M.D.
    The enzymatic carboxylation of phosphoenolpyruvate. II. Purification and properties of liver mitochondrial phosphoenolpyruvate carboxykinase.
    J. Biol. Chem. 241: 2413-2420 (1966). [PMID: 5911620]
  2. Kurahashi, K., Pennington, R.J. and Utter, M.J.
    Nucleotide specificity of oxalacetic carboxylase.
    J. Biol. Chem. 226: 1059-1075 (1957). [PMID: 13438893]

[EC created 1961]