EC - Oxaloacetate decarboxylase

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IntEnz Enzyme Nomenclature


Accepted name:
oxaloacetate decarboxylase
Other names:
oxalacetic acid decarboxylase
oxalate β-decarboxylase
oxaloacetate β-decarboxylase
oxaloacetate carboxy-lyase
Systematic name:
oxaloacetate carboxy-lyase (pyruvate-forming)




The enzyme from Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA. The process is accompanied by the extrusion of two sodium ions from cells. Some animal enzymes require Mn2+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00167 , PROSITE:PDOC50991
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008948
CAS Registry Number: 9024-98-0
UniProtKB/Swiss-Prot: (168) [show] [UniProt]


  1. Dimroth, P.
    Characterization of a membrane-bound biotin-containing enzyme: oxaloacetate decarboxylase from Klebsiella aerogenes.
    Eur. J. Biochem. 115: 353-358 (1981). [PMID: 7016536]
  2. Dimroth, P.
    The role of biotin and sodium in the decarboxylation of oxaloacetate by the membrane-bound oxaloacetate decarboxylase from Klebsiella aerogenes.
    Eur. J. Biochem. 121: 435-441 (1982). [PMID: 7037395]
  3. Herbert, D.
    Oxalacetic carboxylase of Micrococcus lysodeikticus.
    Methods Enzymol. 1: 753-757 (1955).
  4. Horton, A.A. and Kornberg, H.L.
    Oxaloacetate 4-carboxy-lyase from Pseudomonas ovalis chester.
    Biochim. Biophys. Acta 89: 381-383 (1964).
  5. Schmitt, A., Bottke, I. and Siebert, G.
    Eigenschaften einer Oxaloacetat-Decarboxylase aus Dorschmuskulatur.
    Hoppe-Seyler's Z. Physiol. Chem. 347: 18-34 (1966). [PMID: 5972993]

[EC created 1961, modified 1986, modified 2000]