EC 3.8.1.2 - (S)-2-haloacid dehalogenase

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IntEnz Enzyme Nomenclature
EC 3.8.1.2

Names

Accepted name:
(S)-2-haloacid dehalogenase
Other names:
2-haloacid dehalogenase [ambiguous]
2-haloacid halidohydrolase [ambiguous]
2-haloalkanoic acid dehalogenase
2-haloalkanoid acid halidohydrolase
2-halocarboxylic acid dehalogenase II
DL-2-haloacid dehalogenase [ambiguous]
L-2-haloacid dehalogenase
L-DEX
Systematic name:
(S)-2-haloacid halidohydrolase

Reaction

Comments:

Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2. (see also EC 3.8.1.9, (R)-2-haloacid dehalogenase, EC 3.8.1.10, 2-haloacid dehalogenase (configuration-inverting) and EC 3.8.1.11, 2-haloacid dehalogenase (configuration-retaining)).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018784
CAS Registry Number: 37289-39-7
UniProtKB/Swiss-Prot:

References

  1. Goldman, P., Milne, G.W.A. and Keister, D.B.
    Carbon-halogen bond cleavage. 3. Studies on bacterial halidohyrolases.
    J. Biol. Chem. 243: 428-434 (1968). [PMID: 5635785]
  2. Motosugi, M., Esaki, N. and Soda, K.
    Preparation and properties of 2-halo acid dehalogenase from Pseudomonas putida.
    Agric. Biol. Chem. 46: 837-838 (1982).
  3. Klages, M., Krauss, S. and Lingens, F.
    2-Haloacid dehalogenase from a 4-chlorobenzoate-degrading Pseudomonas spec. CBS 3.
    Hoppe-Seyler's Z. Physiol. Chem. 364: 529-535 (1983). [PMID: 6873881]
  4. Diez, A., Prieto, M.I., Alvarez, M.J., Bautista, J.M., Garrido, J. and Puyet, A.
    Improved catalytic performance of a 2-haloacid dehalogenase from Azotobacter sp. by ion-exchange immobilisation.
    Biochem. Biophys. Res. Commun. 220: 828-833 (1996). [PMID: 8607850]
  5. Mörsberger, F.-M., Müller, R., Otto, M.K., Lingens, F. and Kulbe, K.D.
    Purification and characterization of 2-halocarboxylic acid dehalogenase II from Pseudomonas spec. CBS 3.
    Biol. Chem. Hoppe-Seyler 372: 915-922 (1991). [PMID: 1772590]
  6. Köhler, R., Brokamp, A., Schwarze, R., Reiting, R.H. and Schmidt, F.R.J.
    Characteristics and DNA-sequence of a cryptic haloalkanoic acid dehalogenase from Agrobacterium tumefaciens RS5.
    Curr. Microbiol. 36: 96-101 (1998). [PMID: 9425247]
  7. Motosugi, K., Esahi, N. and Soda, K.
    Bacterial assimilation of D- and L-2-chloropropionates and occurrence of a new dehalogenase.
    Arch. Microbiol. 131: 179-183 (1982). [PMID: 7103659]
  8. Kurihara, T., Esaki, N. and Soda, K.
    Bacterial 2-haloacid dehalogenases: structures and reaction mechanisms.
    J. Mol. Catal., B Enzym. 10: 57-65 (2000).
  9. Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi, M., Tsunasawa, S. and Esaki, N.
    Bacterial 2-haloacid dehalogenases: Structures and catalytic properties.
    Pure Appl. Chem. 68: 2097-2103 (1996).

[EC 3.8.1.2 created 1972, modified 2003]