EC 3.7.1.2 - Fumarylacetoacetase

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IntEnz Enzyme Nomenclature
EC 3.7.1.2

Names

Accepted name:
fumarylacetoacetase
Other names:
β-diketonase
fumarylacetoacetate hydrolase
Systematic name:
4-fumarylacetoacetate fumarylhydrolase

Reaction

Comments:

Also acts on other 3,5- and 2,4-dioxo acids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004334
CAS Registry Number: 9032-59-1
UniProtKB/Swiss-Prot:

References

  1. Connors, W.M. and Stotz, E.
    The purification and properties of a triacetic acid-hydrolyzing enzyme.
    J. Biol. Chem. 178: 881-890 (1949).
  2. Edwards, S.W. and Knox, W.E.
    Homogentisate metabolism: the isomerization of maleylacetoacetate by an enzyme which requires glutathione.
    J. Biol. Chem. 220: 79-91 (1956). [PMID: 13319328]
  3. Meister, A. and Greenstein, J.P.
    Enzymatic hydrolysis of 2,4-diketo acids.
    J. Biol. Chem. 175: 573-588 (1948).

[EC 3.7.1.2 created 1961]