EC - Zn2+-exporting ATPase

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IntEnz Enzyme Nomenclature


Accepted name:
Zn2+-exporting ATPase
Other names:
Zn(II)-translocating P-type ATPase
P1B-type ATPase
Systematic name:
ATP phosphohydrolase (Zn2+-exporting)




A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme also exports Cd2+ and Co2+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00139
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016463
UniProtKB/Swiss-Prot: (13) [show] [UniProt]


  1. Beard, S.J., Hashim, R., Membrillo-Hernández, J., Hughes, M.N. and Poole, R.K.
    Zinc(II) tolerance in Escherichia coli K-12: evidence that the zntA gene (o732) encodes a cation transport ATPase.
    Mol. Micorbiol. 25: 883-891 (1997). [PMID: 9364914]
  2. Rensing, C., Mitra, B. and Rosen, B.P.
    The zntA gene of Escherichia coli encodes a Zn(II)-translocating P-type ATPase.
    Proc. Natl. Acad. Sci. USA 94: 14326-14331 (1997). [PMID: 9405611]
  3. Rensing, C., Sun, Y., Mitra, B. and Rosen, B.P.
    Pb(II)-translocating P-type ATPases.
    J. Biol. Chem. 273: 32614-32617 (1998). [PMID: 9830000]
  4. Mills, R.F., Francini, A., Ferreira da Rocha, P.S.C., Baccarini, P.J., Aylett, M., Krijger, G.C. and Williams, L.E.
    The plant P1B-type ATPase AtHMA4 transports Zn and Cd and plays a role in detoxification of transition metals supplied at elevated levels.
    FEBS Lett. 579: 783-791 (2005). [PMID: 15670847]
  5. Eren, E. and Argüello, J.M.
    Arabidopsis HMA2, a divalent heavy metal-transporting PIB-type ATPase, is involved in cytoplasmic Zn2+ homeostasis.
    Plant Physiol. 136: 3712-3723 (2004). [PMID: 15475410]

[EC created 2000, modified 2001, modified 2006]