EC 3.6.3.49 - Channel-conductance-controlling ATPase

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IntEnz Enzyme Nomenclature
EC 3.6.3.49

Names

Accepted name:
channel-conductance-controlling ATPase
Other name:
cystic-fibrosis membrane-conductance-regulating protein
Systematic name:
ATP phosphohydrolase (channel-conductance-controlling)

Reaction

Comments:

ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00185
Structural data: CSA , EC2PDB
Gene Ontology: GO:0005260
UniProtKB/Swiss-Prot: (41) [show] [UniProt]

References

  1. Chen, M. and Zhang, J.T.
    Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes.
    Mol. Membr. Biol. 13: 33-40 (1996). [PMID: 9147660]
  2. Tusnady, G.E., Bakos, E., Varadi, A. and Sarkadi, B.
    Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters.
    FEBS Lett. 402: 1-3 (1997). [PMID: 9013845]
  3. Sheppard, D.N. and Welsh, M.J.
    Structure and function of the CFTR chloride channel.
    Physiol. Rev. 79: S23-S45 (1999). [PMID: 9922375]

[EC 3.6.3.49 created 2000]