EC - Polar-amino-acid-transporting ATPase

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IntEnz Enzyme Nomenclature


Accepted name:
polar-amino-acid-transporting ATPase
Other name:
histidine permease
Systematic name:
ATP phosphohydrolase (polar-amino-acid-importing)



ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. Comprises bacterial enzymes that import His, Arg, Lys, Glu, Gln, Asp, ornithine, octopine and nopaline.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00185
Structural data: CSA , EC2PDB
Gene Ontology: GO:0015426


  1. Kuan, G., Dassa, E., Saurin, N., Hofnung, M. and Saier, M.H., Jr.
    Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases.
    Res. Microbiol. 146: 271-278 (1995). [PMID: 7569321]
  2. Saier, M.H., Jr.
    Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
    Adv. Microb. Physiol. 40: 81-136 (1998). [PMID: 9889977]
  3. Nikaido, K., Liu, P.Q. and Ferro-Luzzi Ames, G.
    Purification and characterization of HisP, the ATP-binding subunit of a traffic ATPase (ABC transporter), the histidine permease of Salmonella typhimurium. Solubilization, dimerization , and ATPase activity.
    J. Biol. Chem. 272: 27745-27752 (1997). [PMID: 9346917]
  4. Walshaw, D.L., Lowthorpe, S., East, A. and Poole, P.S.
    Distribution of a sub-class of bacterial ABC polar amino acid transporter and identification of an N-terminal region involved in solute specificity.
    FEBS Lett. 414: 397-401 (1997). [PMID: 9315727]

[EC created 2000]