EC 3.6.1.61 - Diadenosine hexaphosphate hydrolase (ATP-forming)

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IntEnz Enzyme Nomenclature
EC 3.6.1.61

Names

Accepted name:
diadenosine hexaphosphate hydrolase (ATP-forming)
Other name:
Ndx1
Systematic name:
P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming)

Reactions

Cofactor

Comments:

The enzyme requires the presence of the divalent cations (Mn2+, Mg2+, Zn2+, and Co2+). It hydrolyses P1,P4-bis(5-guanosyl) tetraphosphate very slowly [cf. EC 3.6.1.17, bis(5-nucleosyl)-tetraphosphatase (asymmetrical)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Iwai, T., Kuramitsu, S., Masui, R.
    The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity.
    J. Biol. Chem. 279: 21732-21739 (2004). [PMID: 15024014]

[EC 3.6.1.61 created 2012]