EC 3.6.1.6 - Nucleoside diphosphate phosphatase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 3.6.1.6

Names

Accepted name:
nucleoside diphosphate phosphatase
Other names:
ADPase
CDPase
GDPase
IDPase
NDPase
UDPase
adenosine diphosphatase
adenosinepyrophosphatase
guanosine 5'-diphosphatase
guanosine diphosphatase
inosine 5'-diphosphatase
inosine diphosphatase
nucleoside 5'-diphosphatase
nucleoside-diphosphatase
nucleoside diphosphate phosphohydrolase
thiaminpyrophosphatase
type B nucleoside diphosphatase
type L nucleoside diphosphatase
uridine 5'-diphosphatase
uridine diphosphatase
Systematic name:
nucleoside-diphosphate phosphohydrolase

Reaction

Comments:

The enzyme, which appears to be limited to metazoa, acts on multiple nucleoside diphosphates as well as on D-ribose 5-diphosphate. Specificity depends on species and isoform.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0017110 , GO:0045134
CAS Registry Number: 9027-69-4
UniProtKB/Swiss-Prot: (18) [show] [UniProt]

References

  1. Gibson, D.M., Ayengar, P. and Sanadi, D.R.
    A phosphatase specific for nucleoside diphosphates.
    Biochim. Biophys. Acta 16: 536-538 (1955). [PMID: 14389272]
  2. Horecker, B.L., Hurwitz, J. and Heppel, L.A.
    The synthesis of ribose 5-pyrophosphate and ribose 5-triphosphate.
    J. Am. Chem. Soc. 79: 701-702 (1957).
  3. Yeung, G., Mulero, J. J., McGowan, D. W., Bajwa, S. S., Ford, J. E.
    CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart.
    Biochemistry 39: 12916-12923 (2000). [PMID: 11041856]
  4. Failer, B. U., Braun, N., Zimmermann, H.
    Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase.
    J. Biol. Chem. 277: 36978-36986 (2002). [PMID: 12167635]
  5. Uccelletti, D., O'Callaghan, C., Berninsone, P., Zemtseva, I., Abeijon, C., Hirschberg, C. B.
    ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans.
    J. Biol. Chem. 279: 27390-27398 (2004). [PMID: 15102851]

[EC 3.6.1.6 created 1961]