EC - Diphosphoinositol-polyphosphate diphosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
diphosphoinositol-polyphosphate diphosphatase
Other names:
diphosphoinositol-polyphosphate phosphohydrolase
Systematic name:
diphospho-myo-inositol-polyphosphate diphosphohydrolase



This enzyme hydrolyses the diphosphate bond, leaving a phospho group where a diphospho group had been. It can also act on bis(adenosine) diphosphate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00695
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008486 , GO:0052841 , GO:0052842 , GO:0052840 , GO:0052846 , GO:0052847 , GO:0052843 , GO:0052848 , GO:0052844 , GO:0052845
UniProtKB/Swiss-Prot: (21) [show] [UniProt]


  1. Safrany, S.T., Caffrey, J.J., Yang, X., Bembenek, M.E., Moyer, M.B., Burkhart, W.A. and Shears, S.B.
    A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase.
    EMBO J. 17: 6599-6607 (1998). [PMID: 9822604]
  2. Caffrey, J.J., Safrany, S.T., Yang, X. and Shears, S.B.
    Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family.
    J. Biol. Chem. 275: 12730-12736 (2000). [PMID: 10777568]

[EC created 2002]