EC 3.6.1.45 - UDP-sugar diphosphatase

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IntEnz Enzyme Nomenclature
EC 3.6.1.45

Names

Accepted name:
UDP-sugar diphosphatase
Other names:
UDP-sugar hydrolase
UDP-sugar pyrophosphatase
nucleosidediphosphate-sugar diphosphatase
nucleosidediphosphate-sugar pyrophosphatase
Systematic name:
UDP-sugar sugarphosphohydrolase

Reaction

Cofactor

Comments:

A divalent cation is required for activity. UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. Thus, this enzyme has a specificity distinct from that of ADP-sugar diphosphatase (EC 3.6.1.21). Some but not all enzymes of this class also appear to have 5'-nucleotidase (see EC 3.1.3.5) activity.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00627
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008768
CAS Registry Numbers: 103716-25-2 103716-26-3 57127-20-5
UniProtKB/Swiss-Prot:

References

  1. Garrett, A.R., Johnson, L.A. and Beacham, I.R.
    Isolation, molecular characterization and expression of the ushB gene of Salmonella typhimurium which encodes a membrane bound UDP-sugar hydrolase.
    Mol. Microbiol. 3: 177-186 (1989). [PMID: 2548058]
  2. Glaser, L., Melo, A. and Paul, R.
    Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor.
    J. Biol. Chem. 242: 1944-1954 (1987).

[EC 3.6.1.45 created 1999]