EC - Undecaprenyl-diphosphate phosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
undecaprenyl-diphosphate phosphatase
Other names:
C55-isoprenyl diphosphatase
C55-isoprenyl pyrophosphatase
isoprenyl pyrophosphatase [ambiguous]
undecaprenyl pyrophosphate phosphatase
undecaprenyl pyrophosphate pyrophosphatase
UPP phosphatase
Und-PP pyrophosphatase
UppP [ambiguous]
undecaprenyl-diphosphate phosphohydrolase
Systematic name:
ditrans,octacis-undecaprenyl-diphosphate phosphohydrolase



Isolated from the bacteria Micrococcus lysodeikticus [1], Escherichia coli [2,3,5,6] and Bacillus subtilis [4]. The product of the reaction, ditrans,octacis-undecaprenyl phosphate, is essential for cell wall polysaccharide biosynthesis in these strains.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050380
CAS Registry Number: 9077-80-9
UniProtKB/Swiss-Prot: (647) [show] [UniProt]


  1. Goldman, R. and Strominger, J.L.
    Purification and properties of C55-isoprenylpyrophosphate phosphatase from Micrococcus lysodeikticus.
    J. Biol. Chem. 247: 5116-5122 (1972). [PMID: 4341539]
  2. El Ghachi, M., Bouhss, A., Blanot, D., Mengin-Lecreulx, D.
    The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity.
    J. Biol. Chem. 279: 30106-30113 (2004). [PMID: 15138271]
  3. El Ghachi, M., Derbise, A., Bouhss, A., Mengin-Lecreulx, D.
    Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli.
    J. Biol. Chem. 280: 18689-18695 (2005). [PMID: 15778224]
  4. Bernard, R., El Ghachi, M., Mengin-Lecreulx, D., Chippaux, M., Denizot, F.
    BcrC from Bacillus subtilis acts as an undecaprenyl pyrophosphate phosphatase in bacitracin resistance.
    J. Biol. Chem. 280: 28852-28857 (2005). [PMID: 15946938]
  5. Tatar, L. D., Marolda, C. L., Polischuk, A. N., van Leeuwen, D., Valvano, M. A.
    An Escherichia coli undecaprenyl-pyrophosphate phosphatase implicated in undecaprenyl phosphate recycling.
    Microbiology (Reading, Engl.) 153: 2518-2529 (2007). [PMID: 17660416]
  6. Touze, T., Blanot, D., Mengin-Lecreulx, D.
    Substrate specificity and membrane topology of Escherichia coli PgpB, an undecaprenyl pyrophosphate phosphatase.
    J. Biol. Chem. 283: 16573-16583 (2008). [PMID: 18411271]

[EC created 1978, modified 2002, modified 2012]