EC - Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

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IntEnz Enzyme Nomenclature


Accepted name:
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
Other names:
diadenosine P1,P4-tetraphosphatase
diguanosinetetraphosphatase (asymmetrical)
dinucleoside tetraphosphatase
dinucleosidetetraphosphatase (asymmetrical)
1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
Systematic name:
P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase



Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly, on bis(5'-adenosyl)-tetraphosphate and bis(5'-uridyl)-tetraphosphate [cf. EC bis(5'-nucleosyl)-tetraphosphatase (symmetrical)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00694 , PROSITE:PDOC00695
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004081
CAS Registry Number: 37289-29-5
UniProtKB/Swiss-Prot: (36) [show] [UniProt]


  1. Jakubowski, H. and Guranowski, A.
    Enzymes hydrolyzing ApppA and/or AppppA in higher plants. Purification and some properties of diadenosine triphosphatase, diadenosine tetraphosphatase, and phosphodiesterase from yellow lupin (Lupinus luteus) seeds.
    J. Biol. Chem. 258: 9982-9989 (1983). [PMID: 6309793]
  2. Vallejo, C.M., Lobatón, C.D., Quintanilla, M., Sillero, A. and Sillero, M.A.G.
    Dinucleosidasetetraphosphatase in rat liver and Artemia salina.
    Biochim. Biophys. Acta 438: 304-309 (1976). [PMID: 181087]
  3. Warner, A.H. and Finamore, F.J.
    Isolation, purification, and characterization of P1, P4-diguanosine 5'-tetraphosphate asymmetrical-pyrophosphohydrolase from brine shrimp eggs.
    Biochemistry 4: 1568-1575 (1965). [PMID: 4955726]

[EC created 1972, modified 1976, modified 1986]