EC - Inorganic diphosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
inorganic diphosphatase
Systematic name:
diphosphate phosphohydrolase



Specificity varies with the source and with the activating metal ion. The enzyme from some sources may be identical with EC (alkaline phosphatase) or EC (glucose-6-phosphatase). A form of this enzyme with a molecular mass of about 90 kDa is found in tonoplasts of plants and fungi, where it imports protons from the cytosol into the vacuolar lumen.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00325
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004427
CAS Registry Number: 9024-82-2
UniProtKB/Swiss-Prot: (329) [show] [UniProt]


  1. Bailey, K. and Webb, E.C.
    Purification and properties of yeast pyrophosphatase.
    Biochem. J. 38: 394-398 (1944).
  2. Kunitz, M.
    Crystalline inorganic pyrophosphatase isolated from baker's yeast.
    J. Gen. Physiol. 35: 423-450 (1952).
  3. Rafter, G.W.
    Pyrophosphate metabolism in liver mitochondria.
    J. Biol. Chem. 235: 2475-2477 (1960).

[EC created 1961, modified 2000]