EC - 1-aminocyclopropane-1-carboxylate deaminase

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IntEnz Enzyme Nomenclature


Accepted name:
1-aminocyclopropane-1-carboxylate deaminase
Other names:
1-aminocyclopropane-1-carboxylate endolyase (deaminating)
ACC deaminase
1-aminocyclopropane carboxylic acid deaminase
Systematic name:
1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)




A pyridoxal 5'-phosphate enzyme. The enzyme, found in certain soil bacteria and fungi, catalyses the ring opening of 1-aminocyclopropane-1-carboxylate, the immediate precursor to ethylene, an important plant hormone that regulates fruit ripening and other processes. The enzyme releases an unstable enamine product that tautomerizes to an imine form, which undergoes spontaneous hydrolytic deamination. The enzyme has been used to make fruit ripening dependent on externally added ethylene, as it removes the substrate for endogenous ethylene formation.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008660
CAS Registry Number: 69553-48-6
UniProtKB/Swiss-Prot: (54) [show] [UniProt]


  1. Honma, M. and Shimomura T.
    Metabolism of 1-aminocyclopropane-1-carboxylic acid.
    Agric. Biol. Chem. 42: 1825-1831 (1978).
  2. Yao, M., Ose, T., Sugimoto, H., Horiuchi, A., Nakagawa, A., Wakatsuki, S., Yokoi, D., Murakami, T., Honma, M. and Tanaka, I.
    Crystal structure of 1-aminocyclopropane-1-carboxylate deaminase from Hansenula saturnus.
    J. Biol. Chem. 275: 34557-34565 (2000). [PMID: 10938279]
  3. Thibodeaux, C. J., Liu, H. W.
    Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: characterization of an unusual pyridoxal 5'-phosphate-dependent reaction.
    Biochemistry 50: 1950-1962 (2011). [PMID: 21244019]

[EC created 1981 as EC, transferred 2002 to EC, modified 2014]