EC 3.5.99.6 - Glucosamine-6-phosphate deaminase

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IntEnz Enzyme Nomenclature
EC 3.5.99.6

Names

Accepted name:
glucosamine-6-phosphate deaminase
Other names:
aminodeoxyglucosephosphate isomerase
glucosamine phosphate deaminase
glucosaminephosphate isomerase
phosphoglucosamine isomerase
phosphoglucosaminisomerase
glucosamine-6-phosphate isomerase
GlcN6P deaminase
Systematic name:
2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)

Reaction

Comments:

Formerly EC 5.3.1.10. Isomerization of the aldose-ketose type converts the -CH(-NH2)-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH2-OH, forming 2-deoxy-2-imino-D-arabino-hexitol, which then hydrolyses to yield fructose 6-phosphate and ammonia. N-Acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00894
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004342
CAS Registry Number: 9013-10-9
UniProtKB/Swiss-Prot: (286) [show] [UniProt]

References

  1. Comb, D.G. and Roseman, S.
    Glucosamine metabolism. IV. Glucosamine-6-phosphate deaminase.
    J. Biol. Chem. 232: 807-827 (1958). [PMID: 13403679]
  2. Pattabiraman, T.N. and Bachhawat, B.K.
    Purification of glucosamine 6-phosphate deaminase from human brain.
    Biochim. Biophys. Acta 54: 273-283 (1961). [PMID: 13549465]
  3. Wolfe, J.G., Britton, B.B. and Nakada, H.I.
    Glucosamine degradation by Escherichia coli. III. Isolation and studies of "phosphoglucosaminisomerase".
    Arch. Biochem. Biophys. 66: 333-339 (1957). [PMID: 14484386]
  4. Liu, C., Li, D., Liang, Y. H., Li, L. F., Su, X. D.
    Ring-opening mechanism revealed by crystal structures of NagB and its ES intermediate complex.
    J. Mol. Biol. 379: 73-81 (2008). [PMID: 18436239]

[EC 3.5.99.6 created 1961 as EC 5.3.1.10, transferred 2000 to EC 3.5.99.6]