EC - Aliphatic nitrilase

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IntEnz Enzyme Nomenclature


Accepted name:
aliphatic nitrilase
Systematic name:
aliphatic nitrile aminohydrolase



Preferentially hydrolyses aliphatic nitriles, some of which are apparently not substrates for other known nitrilases (EC Substrates include crotononitrile, acrylonitrile and glutaronitrile.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00712
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018762
CAS Registry Numbers: 143236-44-6 9024-90-2


  1. Kobayashi, M., Yanaka, N., Nagasawa, T. and Yamada, H.
    Primary structure of an aliphatic nitrile-degrading enzyme, aliphatic nitrilase from Rhodococcus rhodochrous K22 and expression of its gene and identification of its active site residue.
    Biochemistry 31: 9000-9007 (1992). [PMID: 1390687]
  2. Pace, H. C., Brenner, C.
    The nitrilase superfamily: classification, structure and function.
    Genome Biol. 2: 0001.1-0001.9 (2001). [PMID: 11380987]

[EC created 1999]