EC 3.5.5.1 - Nitrilase

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IntEnz Enzyme Nomenclature
EC 3.5.5.1

Names

Accepted name:
nitrilase
Other names:
acetonitrilase
benzonitrilase
Systematic name:
nitrile aminohydrolase

Reactions

Comments:

Acts on a wide range of aromatic nitriles including (indol-3-yl)acetonitrile, and also on some aliphatic nitriles, and on the corresponding acid amides. cf. EC 4.2.1.84 nitrile hydratase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00712 , PROSITE:PDOC50263
Structural data: CSA , EC2PDB
Gene Ontology: GO:0000257
CAS Registry Number: 9024-90-2
UniProtKB/Swiss-Prot: (26) [show] [UniProt]

References

  1. Harper, D.B.
    Microbial metabolism of aromatic nitriles. Enzymology of C-N cleavage by Nocardia sp. (rhodochrous group) N.C.I.B. 11216.
    Biochem. J. 165: 309-319 (1977). [PMID: 21655]
  2. Thimann, K.V. and Mahadevan, S.
    Nitrilase. I. Occurrence, preparation, and general properties of the enzyme.
    Arch. Biochem. Biophys. 105: 133-141 (1964). [PMID: 14165487]
  3. Pace, H.C. and Brenner, C.
    The nitrilase superfamily: classification, structure and function.
    Genome Biol. 2: 0001.1-0001.9 (2001). [PMID: 11380987]

[EC 3.5.5.1 created 1965, modified 1989]