EC 3.5.4.30 - DCTP deaminase (dUMP-forming)

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IntEnz Enzyme Nomenclature
EC 3.5.4.30

Names

Accepted name:
dCTP deaminase (dUMP-forming)
Systematic name:
dCTP aminohydrolase (dUMP-forming)

Reaction

Cofactor

Comments:

Requires Mg2+. Is highly specific for dCTP as substrate as dCMP, CTP, CDP, CMP, cytosine or deoxycytosine are not deaminated. While most bacteria require two enzymes to form dUMP from dCTP (EC 3.5.4.13, dCTP deaminase and EC 3.6.1.23, dUTP diphosphatase), the archaeon Methanocaldococcus jannaschii uses a single enzyme to carry out both functions. This enzyme can also act as a dUTP diphosphatase, but more slowly.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033973
UniProtKB/Swiss-Prot:

References

  1. Li, H., Xu, H., Graham, D.E. and White, R.H.
    The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase.
    J. Biol. Chem. 278: 11100-11106 (2003). [PMID: 12538648]

[EC 3.5.4.30 created 2003]