EC 3.5.4.25 - GTP cyclohydrolase II

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IntEnz Enzyme Nomenclature
EC 3.5.4.25

Names

Accepted name:
GTP cyclohydrolase II
Other names:
GTP-8-formylhydrolase
guanosine triphosphate cyclohydrolase II
Systematic name:
GTP 7,8-8,9-dihydrolase (diphosphate-forming)

Reaction

Comments:

Two C-N bonds are hydrolysed, releasing formate, with simultaneous removal of the terminal diphosphate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003935
UniProtKB/Swiss-Prot: (221) [show] [UniProt]

References

  1. Foor, F. and Brown, G.M.
    Purification and properties of guanosine triphosphate cyclohydrolase II from Escherichia coli.
    J. Biol. Chem. 250: 3545-3551 (1975). [PMID: 235552]

[EC 3.5.4.25 created 1984]