EC 3.5.4.19 - Phosphoribosyl-AMP cyclohydrolase

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IntEnz Enzyme Nomenclature
EC 3.5.4.19

Names

Accepted name:
phosphoribosyl-AMP cyclohydrolase
Other names:
PRAMP-cyclohydrolase
phosphoribosyladenosine monophosphate cyclohydrolase
Systematic name:
1-(5-phospho-β-D-ribosyl)-AMP 1,6-hydrolase

Reaction

Comments:

The Neurospora crassa enzyme also catalyses the reactions of EC 1.1.1.23 (histidinol dehydrogenase) and EC 3.6.1.31 (phosphoribosyl-ATP diphosphatase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004635
CAS Registry Number: 37289-22-8
UniProtKB/Swiss-Prot: (359) [show] [UniProt]

References

  1. Minson, A.C. and Creaser, E.H.
    Purification of a trifunctional enzyme, catalysing three steps of the histidine pathway, from Neurospora crassa.
    Biochem. J. 114: 49-56 (1969). [PMID: 4309307]

[EC 3.5.4.19 created 1972, modified 1976, modified 1981, modified 2000]