EC 3.5.1.99 - Fatty acid amide hydrolase

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IntEnz Enzyme Nomenclature
EC 3.5.1.99

Names

Accepted name:
fatty acid amide hydrolase
Other names:
FAAH
oleamide hydrolase
anandamide amidohydrolase
Systematic name:
fatty acylamide amidohydrolase

Reactions

Comments:

Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00494
Structural data: CSA , EC2PDB
Gene Ontology: GO:0103073 , GO:0102077
UniProtKB/Swiss-Prot:

References

  1. Boger, D. L., Fecik, R. A., Patterson, J. E., Miyauchi, H., Patricelli, M. P., Cravatt, B. F.
    Fatty acid amide hydrolase substrate specificity.
    Bioorg. Med. Chem. Lett. 10: 2613-2616 (2000). [PMID: 11128635]
  2. Patricelli, M. P., Lashuel, H. A., Giang, D. K., Kelly, J. W., Cravatt, B. F.
    Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization.
    Biochemistry 37: 15177-15187 (1998). [PMID: 9790682]
  3. Patricelli, M. P., Cravatt, B. F.
    Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase.
    Biochemistry 40: 6107-6115 (2001). [PMID: 11352748]

[EC 3.5.1.99 created 2009]