EC 3.5.1.24 - Choloylglycine hydrolase

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IntEnz Enzyme Nomenclature
EC 3.5.1.24

Names

Accepted name:
choloylglycine hydrolase
Other names:
bile salt hydrolase
choloyltaurine hydrolase
glycocholase
Systematic name:
3α,7α,12α-trihydroxy-5β-cholan-24-oylglycine amidohydrolase

Reaction

Comments:

Also acts on the 3α,12α-dihydroxy-derivative, and on choloyl-taurine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0045302
CAS Registry Number: 37289-07-9
UniProtKB/Swiss-Prot:

References

  1. Nair, P.P., Gordon, M. and Reback, J.
    The enzymatic cleavage of the carbon-nitrogen bond in 3α,7α,12α-trihydroxy-5-β-cholan-24-oylglycine.
    J. Biol. Chem. 242: 7-11 (1967). [PMID: 6016335]
  2. Stellwag, E.J. and Hylemon, P.B.
    Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis.
    Biochim. Biophys. Acta 452: 165-176 (1976). [PMID: 10993]

[EC 3.5.1.24 created 1972]