EC - S2P endopeptidase

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IntEnz Enzyme Nomenclature


Accepted name:
S2P endopeptidase
Other name:
sterol regulatory element-binding protein site 2 protease
Systematic name:




Type example of peptidase family M50. The transcription factors SREBP-1 and -2 are synthesized as precursor proteins that are attached to the membranes of the endoplasmic reticulum and two cleavages are needed to release the active factor so that it can move to the nucleus. This enzyme cleaves the second of these, and is thus the "site 2 protease", S2P.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB


  1. Brown, M.S., Ye, J., Rawson, R.B. and Goldstein, J.L.
    Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans.
    Cell 100: 391-398 (2000). [PMID: 10693756]

[EC created 2003]