EC 3.4.24.84 - Ste24 endopeptidase

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IntEnz Enzyme Nomenclature
EC 3.4.24.84

Names

Accepted name:
Ste24 endopeptidase
Other names:
prenyl protein-specific endoprotease 1
CAAX prenyl protease 1
Systematic name:
-

Reaction

Cofactor

Comments:

Type example of peptidase family M48. One of two enzymes that can catalyse this processing step for mating a-factor in yeast. Subsequently, the S-isoprenylated cysteine residue that forms the new C-terminus is methyl-esterified and forms a hydrophobic membrane-anchor.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Tam, A., Schmidt, W.K. and Michaelis, S.
    The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor.
    J. Biol. Chem. 276: 46798-46806 (2001). [PMID: 11581258]

[EC 3.4.24.84 created 2003]