EC 3.4.24.82 - ADAMTS-4 endopeptidase

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IntEnz Enzyme Nomenclature
EC 3.4.24.82

Names

Accepted name:
ADAMTS-4 endopeptidase
Other name:
aggrecanase-1
Systematic name:
-

Reaction

Cofactor

Comments:

In peptidase family M12. Thought to be biologically significant for the degradation of the aggrecan component of cartilage matrix.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Westling, J., Fosang, A.J., Last, K., Thompson, V.P., Tomkinson, K.N., Hebert, T., McDonagh, T., Collins-Racie, L.A., LaVallie, E.R., Morris, E.A. and Sandy, J.D.
    ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.
    J. Biol. Chem. 277: 16059-16066 (2002). [PMID: 11854269]

[EC 3.4.24.82 created 2003]